I’m always looking for alternatives to acid blocking medications for acid reflux and gastroesophageal reflux disease (GERD) since long term use of these medications is associated with multiple nutrient deficiencies and associated health risks, including deficiencies in iron, calcium, magnesium, zinc, vitamin B12, and protein.

D-limonene is a major constituent in citrus peel oils and has been used as a food flavoring for decades. As a supplement it exhibits gastric acid neutralizing properties and supports normal peristalsis, the wave-like contraction and relaxation of the GI tract that moves food through it; it also acts as a solvent for cholesterol and has been used to dissolve gallstones. It has antioxidant & anti-inflammatory properties and may have anti-cancer/anti-tumor properties. While I haven’t used D-limonene myself, several clinical trials are very encouraging with symptoms of acid reflux significantly reduced in as little as two weeks for 75-90% of participants compared to 20% in the placebo groups. Side-effects are rare and may include abdominal pain, nausea, skin rash, & vomiting. Contraindications include amiodarone, amitriptyline, carbamazepine, cimetidine, diclofenac, fluconazole, fluvoxamide, glipizide, ibuprofen, losartan, lovastatin, meloxicam, paroxetine, prednisone, omeprazole, rifampin, secobarbitol, ticlopidine, topiramate, warfarin, and zafirlukast.

Standard dosage of D-limonene for acid reflux is 500mg daily or 1000mg every other day and is used instead of acid blocking drugs (PPIs or H2 blockers). In clinical trials D-limonene has been used daily for up to a year without long term adverse effects.

Disclaimer: The content herein is not intended to be a substitute for professional medical advice. It is not meant to diagnosis, cure, or treat any medical condition. Always consult a physician or other qualified healthcare provider with questions regarding a medical condition and before starting new diets and dietary supplements. Not all diets or supplements are appropriate for all people or all health conditions.

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